Jun Tohyama Selected Research

Focal cortical dysplasia of Taylor

1/2022	Sirolimus for epileptic seizures associated with focal cortical dysplasia type II.
7/2021	A Single-Arm Open-Label Clinical Trial on the Efficacy and Safety of Sirolimus for Epileptic Seizures Associated with Focal Cortical Dysplasia Type II: A Study Protocol.

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Jun Tohyama Research Topics

Disease

13	Seizures (Absence Seizure) 02/2022 - 08/2007
6	Infantile Spasms (West Syndrome) 01/2022 - 08/2007
6	Brain Diseases (Brain Disorder) 01/2021 - 09/2006
5	Epilepsy (Aura) 01/2022 - 06/2010
4	Neurodevelopmental Disorders 02/2022 - 01/2015
2	Focal cortical dysplasia of Taylor 01/2022 - 07/2021
2	Neoplasms (Cancer) 08/2016 - 02/2016
2	Disorders of Excessive Somnolence (Hypersomnia) 07/2016 - 09/2006
2	Status Epilepticus (Complex Partial Status Epilepticus) 06/2014 - 03/2008
2	Febrile Seizures (Febrile Seizure) 03/2008 - 01/2008
1	Partial Epilepsies (Epilepsy, Partial) 01/2022
1	Focal Cortical Dysplasia 01/2022
1	Spasm (Spasms) 01/2022
1	Body Weight (Weight, Body) 01/2022
1	CDKL5 deficiency disorder 04/2021
1	Amnesia (Dissociative Amnesia) 01/2021
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2021
1	Autism Spectrum Disorder 01/2018
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2018
1	Atrophy 09/2017
1	Peripheral Nervous System Diseases (PNS Diseases) 03/2017
1	Polyneuropathies (Polyneuropathy) 03/2017
1	Pulmonary Alveolar Proteinosis 01/2017
1	Lung Diseases (Lung Disease) 01/2017
1	Autistic Disorder (Autism) 01/2017
1	Methylenetetrahydrofolate reductase deficiency 09/2016
1	Hepatocellular Carcinoma (Hepatoma) 08/2016
1	Infarction (Infarctions) 07/2016
1	Coma (Comas) 07/2016
1	Myoclonus (Nocturnal Myoclonus) 03/2016
1	Alopecia (Baldness) 03/2015
1	Neurocutaneous Syndromes (Phakomatoses) 03/2015
1	Motor Skills Disorders (Motor Skills Disorder) 01/2015
1	Fabry Disease (Fabry's Disease) 04/2013
1	Uniparental Disomy 10/2011
1	Temple syndrome 10/2011
1	Frontal Lobe Epilepsy (Epilepsy, Supplementary Motor) 07/2011
1	Quadriplegia (Spastic Quadriplegia) 06/2010
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 11/2009
1	Subacute Sclerosing Panencephalitis (SSPE) 12/2008
1	PEHO syndrome 05/2008
1	Paralysis (Palsy) 03/2008
1	Intellectual Disability (Idiocy) 08/2007
1	Megalencephaly 08/2007
1	Hydrocephalus (Hydrocephaly) 08/2007
1	Infantile Epileptic-Dyskinetic Encephalopathy 08/2007

Drug/Important Bio-Agent (IBA)

6	Anticonvulsants (Antiepileptic Drugs)IBA 07/2021 - 11/2009
3	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2022 - 12/2011
3	SpectrinIBA 09/2017 - 06/2010
2	Carbamazepine (Tegretol)FDA LinkGeneric 02/2022 - 01/2021
2	Sirolimus (Rapamycin)FDA Link 01/2022 - 07/2021
2	perampanelIBA 01/2021 - 01/2021
2	EnzymesIBA 01/2018 - 04/2013
2	Folic Acid (Vitamin M)FDA LinkGeneric 03/2017 - 09/2016
2	CytokinesIBA 01/2017 - 01/2008
2	OrexinsIBA 07/2016 - 09/2006
2	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2011 - 09/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2008 - 01/2008
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 12/2008 - 01/2008
1	Glutamic Acid (Glutamate)FDA Link 02/2022
1	CyclinsIBA 04/2021
1	Nuclear Localization Signals (Nuclear Localization Signal)IBA 01/2021
1	Levetiracetam (Keppra)FDA LinkGeneric 01/2021
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2018
1	Biological ProductsIBA 01/2018
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2018
1	Leucovorin (Folinic Acid)FDA Link 03/2017
1	Surface-Active Agents (Surfactants)IBA 01/2017
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2017
1	Cell Adhesion MoleculesIBA 01/2017
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 09/2016
1	gadolinium ethoxybenzyl DTPA FDA Link 08/2016
1	Peptides (Polypeptides)IBA 07/2016
1	dicarboxydine (DCD)IBA 01/2015
1	Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA 09/2013
1	GalactosidasesIBA 04/2013
1	globotriaosyl lysosphingolipidIBA 04/2013
1	Genetic Markers (Genetic Marker)IBA 10/2011
1	A-Form DNA (A-DNA)IBA 10/2011
1	stiripentolIBA 11/2009
1	Biomarkers (Surrogate Marker)IBA 12/2008
1	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 05/2008
1	Tissue Inhibitor of Metalloproteinase-1IBA 03/2008
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2008
1	Metalloproteases (Metalloproteinases)IBA 03/2008
1	Matrix Metalloproteinases (MMPs)IBA 03/2008
1	Interleukin-10 (Interleukin 10)IBA 01/2008
1	Interferon-gamma (Interferon, gamma)IBA 01/2008
1	Interleukin-6 (Interleukin 6)IBA 01/2008
1	Interleukin-2 (IL2)IBA 01/2008
1	Interleukin-4 (Interleukin 4)IBA 01/2008
1	polyalanineIBA 08/2007
1	Radioisotopes (Radionuclides)IBA 08/2007

Therapy/Procedure

8	Therapeutics 01/2022 - 09/2004
1	Ketogenic Diet 01/2022
1	Drug Tapering 01/2022
1	Precision Medicine 01/2022
1	Aftercare (After-Treatment) 02/2016
1	Anesthesia 03/2015
1	Induced Hyperthermia (Thermotherapy) 06/2014